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    Apr 12, 2011 · As BMX is a kinase, we validated the activation of BMX in GSCs by measuring its specific phosphorylation on Tyr 40 [pBMX Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science.

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  • BMX Negatively Regulates BAK Function, Thereby Increasing

    BMX has been implicated in the development of prostate cancer (22, 40), where elevated levels may compensate for androgen deprivation (28, 41). Furthermore, a requirement of BMX for glioblastoma stem cell survival has been identified , as well as a role for BMX in the pathogenesis of bladder cancer .

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